National Headlines

New Insights into how Gout Happens ~MedPage Today

  • By Nancy Walsh, Senior Staff Writer, MedPage Today

ORLANDO — Gout may be an ancient disease, with arthritis of the big toe having been described in Egypt in 2,600 BC, but only now are the underlying pathophysiologic events being elucidated and understood. Current thinking on the pathogenesis of gout, which today affects more than 8 million Americans — 4% of the population — has evolved into the “mobilization flare” hypothesis. In this disease conceptualization, when serum urate levels exceed 6 mg/dL, even in asymptomatic individuals, deposition of urate crystals in the synovium and other tissues begins.



Categories: National Headlines