2018 CMT FORUM: “What is the Endocannabinoid System & Role of the Endocannabinoid System?” ~Coming this Oct 25-27, 2018
BY From Wikipedia, the free encyclopedia
| The endocannabinoid system
) is a biological system composed of endocannabinoids, which are endogenous lipid
-based retrograde neurotransmitters
that bind to cannabinoid receptors
, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system
(including the brain
) and peripheral nervous system
. The endocannabinoid system is involved in regulating a variety of physiological and cognitive processes
– and postnatal
, and memory
, and in mediating the pharmacological
effects of cannabis
The ECS is also involved in mediating some of the physiological and cognitive effects of voluntary physical exercise
in humans and other animals, such as contributing to exercise-induced euphoria
as well as modulating locomotor activity
and motivational salience
In humans, the plasma
concentration of certain endocannabinoids (i.e., anandamide
) have been found to rise during physical activity;
since endocannabinoids can effectively penetrate the blood–brain barrier
, it has been suggested that anandamide, along with other euphoriant
neurochemicals, contributes to the development of exercise-induced euphoria in humans, a state colloquially referred to as a runner’s high
COMING THIS OCTOBER 2018 A New Session — “Medical Marijuana & Latest Research, Utility & Legal Challenges and More” — Explore new ideas like these, learn trends, best practices, network with others … Register Early … Group Discounts also avail. OCT 25-27, 2018 — http://www.conciergemedicineFORUM.com
Dr. Sanjay Gupta to Jeff Sessions (April 2018): Medical marijuana could save many addicted to opioids
The drug overdose scourge claimed about 68,000 US lives in 2017
, just over 45,000 of them from opioids alone. Every day, 115 Americans die from opioid overdoses. It has fueled a decline in an entire country’s life expectancy
and will be remembered as a sad and tragic chapter in our collective history.
These are desperate times, and while some may consider making medical marijuana widely available to be a desperate measure, the evidence has become increasingly clear of the important role cannabis can have.
We have seen real-world clues of medical marijuana’s benefits. Researchers from the Rand Corp., supported by the National Institute on Drug Abuse
, conducted “the most detailed examination of medical marijuana and opioid deaths to date” and found something few initially expected. The analysis showed an approximately 20% decline in opioid overdose deaths between 1999 and 2010 in states with legalized medical marijuana and functioning dispensaries.
It’s not the first time this association between medical marijuana and opioid overdose has been found
. Though it is too early to draw a cause-effect relationship, these data suggest that medicinal marijuana could save up to 10,000 lives every year.
Published in final edited form as:
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few. An impediment to the development of cannabinoid medications has been the socially unacceptable psychoactive properties of plant-derived or synthetic agonists, mediated by CB1 receptors. However, this problem does not arise when the therapeutic aim is achieved by treatment with a CB1 receptor antagonist, such as in obesity, and may also be absent when the action of endocannabinoids is enhanced indirectly through blocking their metabolism or transport. The use of selective CB2 receptor agonists, which lack psychoactive properties, could represent another promising avenue for certain conditions. The abuse potential of plant-derived cannabinoids may also be limited through the use of preparations with controlled composition and the careful selection of dose and route of administration. The growing number of preclinical studies and clinical trials with compounds that modulate the endocannabinoid system will probably result in novel therapeutic approaches in a number of diseases for which current treatments do not fully address the patients’ need. Here, we provide a comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy.