Source: The Lancet Respiratory Medicine; Citation(s) Table 2. Symptoms, comorbidities, and treatments of patients with severe SARS-CoV-2 pneumonia; Citation/Source: Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China; 2020, Anaesthesia Critical Care and Pain Medicine; Download Table …

Source: Evidence Resource, Doctor Evidence; COVID-19 …; PICO(T) Search Query and Summary by Evidenza Precision Medicine.

PICO(T) Question

“Where’s the Medical Evidence That Says Ventilators Improve/Worsen the Survival Rate In Patients With COVID-19?”

Link(s) to Relevant Study(s)

1. Published: 24 February 2020; The Lancet; Respiratory Medicine; Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China; 2020, Anaesthesia Critical Care and Pain Medicine; View Table; https://doi.org/10.1016/S2213-2600(20)30079-5

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Summary (or Screen Shot) of Relevant Data Specific to Question

• The mortality rate in patients with SARS-CoV-2 infection in our cohort is higher than that previously seen in critically ill patients with SARS. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• In a cohort of 38 critically ill patients with SARS from 13 hospitals in Canada, 29 (76%) patients required mechanical ventilation, 13 (43%) patients had died at 28 days, and six (16%) patients remained on mechanical ventilation.⁸ Source: RA Fowler, SE Lapinsky, D Hallett, et al.Critically ill patients with severe acute respiratory syndrome; JAMA, 290 (2003), pp. 367-373; View Record in Scopus; Google Scholar; View in article)
• Mechanical ventilation is the main supportive treatment for critically ill patients. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• This is a retrospective study. The data in this study permit a preliminary assessment of the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. Further studies are still needed. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• The mortality of critically ill patients with SARS-CoV-2 pneumonia is high. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• The survival term of the non-survivors is likely to be within 1–2 weeks after ICU admission. Older patients (>65 years) with comorbidities and ARDS are at increased risk of death. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• The severity of SARS-CoV-2 pneumonia poses great strain to hospital critical care resources, especially if they are not adequately staffed or resourced. Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext
• This online publication has been corrected. The corrected version first appeared at thelancet.com/respiratory on February 28, 2020; Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30079-5/fulltext

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