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JAMA Network: Evaluating Progression of Depression Symptoms After Breast Cancer Diagnosis in Women



Charles C, Bardet A, Larive A, et al. Characterization of Depressive Symptoms Trajectories After Breast Cancer Diagnosis in Women in France. JAMA Netw Open. 2022;5(4):e225118. doi:10.1001/jamanetworkopen.2022.5118

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Key PointsQuestion  Can distinct longitudinal patterns of depressive symptoms be characterized from diagnosis to 3 years after treatment for breast cancer?

Findings  In this cohort study of 4803 women with breast cancer, 6 trajectory groups that described the heterogeneity in the expression of depressive symptoms were identified. The trajectory groups with depressive symptoms differed from the noncases group (without depressive symptoms) by household income, previous psychiatric hospitalizations, obesity, moderate to high levels of fatigue, and depression at diagnosis.

Meaning  Findings of this study suggest that characterization of depressive trajectory groups after breast cancer diagnosis needs further validation but is a key step toward personalized management of patients at risk of depression, a common comorbidity in breast cancer associated with poorer prognosis.

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