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JAMA Internal Medicine | Daily Low-Dose Aspirin, Risk of Serious Falls, Fractures in Healthy Older Adults

Key PointsQuestion  Does daily low-dose aspirin reduce fractures and serious falls in healthy older people?

Findings  In this substudy of a randomized placebo-controlled trial, the risk of first fracture was similar in the aspirin and placebo groups, but the risk of serious fall was statistically significantly greater in the aspirin group (total falls 884 vs 804).

Meaning  The findings indicate a potential additional risk for the use of low-dose aspirin in older people.



Barker AL, Morello R, Thao LTP, et al. Daily Low-Dose Aspirin and Risk of Serious Falls and Fractures in Healthy Older People: A Substudy of the ASPREE Randomized Clinical Trial. JAMA Intern Med. Published online November 07, 2022. doi:10.1001/jamainternmed.2022.5028


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