Findings In this cohort study of 314 998 participants with over 12 years of follow-up, the study team observed that prefrailty and frailty were associated with a 26% and 87% increased risk of PD, respectively. The genetic risk of PD modified the association between frailty and PD.
Meaning These findings indicate that physical frailty is a potential risk factor for PD and the assessment and management of frailty might have clinical significance in the at-risk population.
Zheng Z, Lv Y, Rong S, Sun T, Chen L. Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease. JAMA Neurol. Published online March 13, 2023. doi:10.1001/jamaneurol.2023.0183
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