Question Is the association between frequent aspirin use and reduced risk of ovarian cancer modified by genetic susceptibility to ovarian cancer, assessed using a polygenic score (PGS)?
Findings In this pooled analysis of 8 case-control studies from the Ovarian Cancer Association Consortium, including 4476 case patients and 6659 control participants, there was no evidence of effect modification by the PGS. Consistent associations between frequent aspirin use and reduced risk of ovarian cancer were observed for individuals with a PGS less than and greater than the median.
Meaning The findings of this study suggest that frequent aspirin use may lower risk of ovarian cancer regardless of an individual’s genetic susceptibility to ovarian cancer.
Hurwitz LM, Webb PM, Jordan SJ, et al. Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility. JAMA Netw Open. 2023;6(2):e230666. doi:10.1001/jamanetworkopen.2023.0666