Editorial, By Zsofia K. Stadler, MD; Deborah Schrag, MD, MPH;
EMBARGOED FOR RELEASE: 4 P.M. (ET), MONDAY, JUNE 5, 2023
Approximately 10% of patients diagnosed with cancer have a germline variant in a gene that increases susceptibility to cancer.1 The most common examples include germline pathogenic variants (mutations) in BRCA1 and BRCA2, which are associated with an increased risk of breast, ovarian, pancreatic, and prostate cancer, and germline pathogenic variants in MLH1, MSH2, MSH6, and PMS2 (Lynch syndrome), which are associated with increased risk of colorectal cancer, endometrial cancer, and other cancer types.
SOURCE: Free access to the full-text article This link will be live at the embargo time *June 5, 2023; 3pm CT; https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.9526?guestAccessKey=25ebf227-5d6d-4d77-8b38-6dcfeef179d3&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=060523
