Sequencing.com Founder and CMT Faculty/Speaker on Megyn Kelly TODAY — Dr. Brandon COLBY Talks Rare Disease & Whole Genome Testing …
“A first-rate, translational medicine scientist [e.g. speaking about one of the Genome Lecturers on Friday, October 27th] is also a first-rate teacher of practicing physicians about the most timely and important current clinical topic.” ~S.B., MD., 2017 Physician Attendee, Arizona
LISTEN | EXCLUSIVE CMT INTERVIEW| “Genetic Testing 101” An Interview with Geneticist, Author and CEO, Brandon Colby, MD @ THE CMT FORUM in ATLANTA, GA USA — Coming October 26-27, 2018 … Learn More …
“What would happen if a physician were to begin speaking to a patient’s future potential rather than their past performance?” adds Colby. “Where the practice of medicine may fall short, a story is often found in our DNA that will provide clarity. Instead of waiting for sickness to occur, the clarity provided by a patient’s DNA can empower a Concierge physician to create a personalized plan for optimizing each patient’s health and longevity.”
In this new DocPreneur Podcast Episode, episode 100, we interview a very special physician and guest, Brandon Colby, MD, the founder of Sequencing.com, Evidenza Precision Medicine Advisory Board Member and author of Outsmart Your Genes.
Support For Broader Use of Limited Genetic Testing and Whole Genome Sequencing in Concierge Medicine
The accuracy of whole genome sequencing is quickly improving and the cost is quickly dropping. Within the next few years, this technology will be widely used by Concierge Physicians in the daily clinical care of their patients.
Genetics usually refers to the study of individual genes and their role in disease or inheritance. Genomics refers to an individual’s entire genomic make-up. Genomics looks at the genetic sequence of genes, and their structure and function as well as the interactions between genes. An easy way to think about genetic testing is to compare it to a book, because genetics is truly our Instruction Manual of Life and genetic testing is simply a way to proofread each person’s Instruction Manual for potential typos, according to Sequencing.com.
“This is cool stuff [Evidence Based Medicine In Concierge Care]!” ~K.W., MD, 2017 CMT FORUM, Physician Attendee, Illinois
The Concierge Medicine Physician can, should [and currently is] acting as the informed fiduciary, shepherding the patient treatment process so as to make informed decisions with actionable data, together, with their patients. Advanced DNA research and whole genome sequencing have powerful applications, says trade publication, Concierge Medicine Today. Companies see Concierge Physicians as the ideal delivery model, allowing people to learn more about their DNA and make informed, data-driven decisions for their future under the direction and support of their involved [Concierge] physician, to live a healthier life.
Use and Application of Pharmacogenomics Inside Concierge Medicine Is Setting A Standard
RELATED STORY | DOwNLOAD NOW | PRECISION MEDICINE | CMT FORUM | ATL.
Pharmacogenomics is the combination of pharmacology and genomics. It involves the study of genetic variations that influence an individual’s response to specific drugs. Pharmacology is the part of science that studies how drugs work. Genomics is the study of a person’s genome including the interactions of those genes with each other and with the person’s environment. Just as decision aids now alert prescribers that the patient takes a supplement that may interact with a prescription, these tests would alert the physician and prescriber that the patient is a poor metabolizer of a particular drug. While one pharmacology treatment approach may work well for one individual, the same approach may not be effective or may cause adverse drug effects in other patients. The implementation of pharmacogenomics helps physicians make informed treatment decisions. This can lead to better patient outcomes by decreasing adverse drug events and by increasing the effectiveness of drugs using data, research, science and the analysis and interpretation of the data by a licensed Physician.
The notion of individual genetic variability has long been accepted and promoted within both the scientific community and the healthcare industry. Advances in molecular testing, and completion of the mapping of the human genome, in particular, give credence to the fact that patients respond differently to medications based upon their individual genetic makeup. Such advancements brought about the concept of personalized medicine, the practice of using an individual’s genetic profile to guide decisions for the prevention, treatment, and diagnosis of disease. Correspondingly, a major problem is the variability of drug efficacy from patient to patient. While some patients complain about lack of effectiveness, other patients suffer from adverse drug events (ADEs). Personalized medicine has the ability to alleviate the burden of individual genetic variability and the resulting varied drug responses across different patient populations. Patient non-adherence to medications as prescribed is a significant economic burden; the resulting estimated annual healthcare costs are close to $3 billion in the United States. The benefits of pharmacogenomics testing to patient adherence are frequently overlooked. Patients fail to take their medications for a number of reasons, such as the general sense that the medications do not work and anxieties related to the possible side effects listed within drug labels. For the non-adherent subset of the patient population, pharmacogenomics testing can serve as positive reinforcement and incentive for patients to take their prescribed medications. Pharmacogenomics test results provide personalized, actionable facts for patients.
Concierge Medicine Today cautions that in order to make this information actionable for patients, a Physician must fully integrate pharmacogenomics into system-wide prescribing practices. After years of thoughtful consideration, careful research and review and countless hours of dialogue with various physicians and companies, we recommend Concierge Medicine Physicians begin to make personal genomic data information and tests available to patients. However, the type of test matters. There are a number of offerings in the marketplace with more to come in the years ahead as these tests become more mainstream. Comprehensive screenings with more than 50 well-established pharmacogenomic genes in a single, cost-effective test will be able to provide medically actionable and clinically relevant data, allowing Concierge Physicians and their patients to make more informed and thoughtful treatment decisions.
More and more people are getting portions of their genome sequenced through services like 23andMe, Pathway Genomics, or Veritas, to name but a few, whether out of curiosity, for health reasons, or to explore their genetic ancestry. But once that test has been completed, once the analysis has been run, what else can consumers do with their data? In an ideal world they would be able to call up other tests, or to be able to use their information to make more informed lifestyle choices. Or, as my colleague and I considered, even donate it to research.
In this special 100th episode we discuss:
- What Is Genetic Testing and Why Is It Important to Our Health?
- What type of different DNA tests are available and how do you know what is accurate and actionable insight?
- What type of reports are available?
- What is Precision Medicine?
- How will the future of patient care be impacted by personal genomics?
- And so much more!
“The genetic revolution has already begun, and it is having far-reaching effects on healthcare right now,” said Brandon Colby, MD. “Our knowledge of how to use this information is increasing at an exponential rate. What this means is that we can now start to integrate genetics into our everyday lives. With comprehensive genetic testing, we launch an innovative strategy against disease, attacking it before it even manifests. Genetic testing, therefore, provides a new counter-offensive in our war against Alzheimer’s, cancer, heart disease, and many other diseases that have plagued our civilization for centuries. This is the most exciting, and potentially groundbreaking, medical development of this century.”
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